Dermatitis herpetiformis is the result of an immunologic response to chronic stimulation of the gut mucosa by dietary gluten. It can be effectively treated with medication plus a glutenfree diet. Dh affects fewer people than coeliac disease, at around 1 in 10,000 people. Ii hospital universitario jose ramon lopez tabrane.
It is intensely itchy, even when only appearing as a mild rash. Dermatitis herpetiformis duhrings disease duhring disease disease, duhring disease, duhrings duhrings disease. Dermatitis herpetiformis, also known as dh and duhrings disease, is a chronic skin condition caused by a reaction to gluten ingestion. Is a pruritic and blistering disease, related to glutensensitive. Dermatitis herpetiformis is a skin condition where you develop a very itchy rash. As just stated, dif of uninvolved skin collected in the perilesional site is the gold standard for the diagnosis of dh. Dh can appear at any age, but is most commonly diagnosed in those between the ages of 15 and 40. Incidence and prevalence of dermatitis herpetiformis in western sweden. It is caused by intolerance to a food ingredient called gluten. Pdf dermatitis herpetiforme en joven con enfermedad. Despite the name, it is not related to the herpes virus.
Dermatitis herpetiformis is linked to a condition called coeliac disease, which is also caused by gluten intolerance. Dermatitis herpetiformis is an autoimmune blistering disease dermatitjs appears as a cutaneous manifestation of gluten intolerance. Its more common in men than women and is rare in children. Dermatitis herpetiformis dh is a chronic, intensely itchy, blistering skin manifestation of glutensensitive enteropathy, commonly known as celiac disease. Dermatitis herpetiformis dh is a rare, and intensely itchy, chronic skin condition associated with gluten enteropathy, although few patients have significant gastrointestinal. The vast majority of patients with dh also have an associated gluten sensitive enteropathy like celiac disease. The rash is not related to either dermatitis or herpes, but is a specific chronic skin condition. Dermatitis herpetiformis dh, also known as duhringbrocq dermatitis, is a chronic, recurrent disease, secondary to gluten hypersensitivity which main clinical manifestation is the occurrence of a papulovesicular pruriginous rash. Dermatitis herpetiforme bramwel mendoza barrera mpi 2. Dermatitis herpetiforme trastornos dermatologicos manual msd. Dermatitis herpetiformis dh is a chronic skin condition associated with coeliac disease.
Dermatitis herpetiformis dh or duhringbrocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes hla dr3, hla dqw2, found in 8090% of cases. Dh is a rash that affects about 10 percent of people with celiac disease. Dermatitis herpetiformis dh is a subepidermal bullous disease characterized by chronic recurrence of itchy, erythematous papules, urticarial wheals and grouped vesicles that appear symmetrically on the. Dermatitis herpetiformis celiac disease foundation. Dermatitis herpetiformis dh is a very itchy rash consisting of bumps and blisters. Sometimes, a combination of both patterns, consisting in granular iga deposition along the basement. The condition is extremely itchy, and the desire to scratch may be overwhelming. Dermatitis herpetiformis as a presentation of celiac disease. The diagnosis and treatment of dermatitis herpetiformis. Dermatitis herpetiformis dh is an autoimmune skin condition linked to coeliac disease. Rituximab treatment for dermatitis herpetiformis in the setting of type 1 diabetes mellitus, celiac disease, vitiligo, autoimmune hemolytic anemia, and autoimmune thrombocytopenia. Dermatitis herpetiformis is characterized by intensely itchy, chronic papulovesicular eruptions, usually distributed symmetrically on extensor surfaces buttocks, back of neck, scalp, elbows, knees, back, hairline, groin, or face 616 the blisters vary in size from very small up to 1 cm across. Dermatitis herpetiformis for health care professionals.
Wheat protein specifically is composed of 68% gliadin and 32% glutamin, therefo. What is dermatitis herpetiformis dermatitis herpetiformis is a rare but persistent immunobullous disease that has been linked to coeliac disease the american spelling is celiac, a glutensensitive enteropathy the name herpetiformis is derived from the tendency for blisters to appear in clusters, resembling herpes simplex. Vesicles dissected with crusts and residual hypopigmented macules on the knees contain starch, lipids and proteins gliadin, glutenin, albumin and globumin. Dermatitis herpetiformis is a skin condition that results from gluten sensitivity. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Dermatitis herpetiformis is a disease of the skin caused by the deposition of iga in the papillary dermis, which triggers an immunologic cascade, resulting in neutrophil recruitment and complement activation. Pdf novedades en dermatosis ampollosas autoinmunitarias.